New research out of the University of Texas Medical Branch potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a major threat to global health.
, UTMB's scientists document how a new drug from Zalgen Labs successfully cured cynomolgus monkeys infected with LassaThere currently is no approved treatment for the disease, which is estimated to infect 300,000 to 500,000 people a year across the region and cause at least 5,000 deaths annually. Women and children are at the highest risk from Lassa, which is characterized by bleeding and coagulation abnormalities, with overall mortality rates exceeding 25% and reaching 50% during epidemics.
Though less common, human-to-human transmission is caused through exposure to blood or secretions and through sexual contact. The UTMB research shows the potential of Zalgen Labs' Arevirumab-3 therapeutic, a monoclonal antibody cocktail, as a treatment against all major strains of the disease in advanced stages.
The results indicated Arevirumab-3 potentially could be used to treat humans infected with Lassa virus.
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