Researchers characterize and predict post-acute sequelae of SARS-CoV-2 infection medrxivpreprint umichsph umichmedicine SARSCoV2 infection COVID19 coronavirus covid PASC
By Bhavana KunkalikarOct 25 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers characterized and predicted post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection.
The study involved eligible individuals who were patients of Michigan Medicine and who were diagnosed with COVID-19 or tested positive for real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 infection between 10 March 2020 and 31 August 2022. Data from RT-PCR tests were gathered for employee screening, standard screening at hospital admission, and routine screening before treatments. Symptomatic as well as asymptomatic subjects participated in the study.
Additionally, the team divided PASC patients into groups according to ICD10 diagnoses that corresponded to 29 phenotypic concepts that had previously been reported as typical PASC symptoms and that were simultaneously recorded with their initial PASC diagnoses.
Almost 34.3% of individuals reported shortness of breath, 30.6% experienced anxiety, 28.5% had fatigue and malaise, 27.2% had depression, 25.4% suffered from sleep disturbances, 23.6% reported asthma, 21.4% experienced headaches, 13.8% had migraine, 13.0% had a cough, and 12.6% had joint pain. All of the 29 PASC symptoms that were examined were enriched, with 27 of them reaching phenome-wide significance and two did not.