Mount Sinai researchers have developed a novel, automated measure of analyzing sleep studies to determine the severity and risk of mortality in patients with obstructive sleep apnea, a chronic sleep disorder that affects about 30 million people in the United States.
The study findings, which provide a validated tool to better manage sleep apnea and promote preventive care, were published in theThe Mount Sinai Sleep and Circadian Analysis Group developed an automated breath-by-breath measure called ventilatory burden that assesses the proportion of small breaths during a routine sleep study. This novel measure is not dependent on the consequences of hypoxemia, or a low level of oxygen in the blood, and the awakenings seen in obstructive sleep apnea patients.
Furthermore, calculation of AHI is influenced by various variables including scoring rules and other highly subjective baselines for breathing and oxygen saturation, rather than airway obstruction alone. AHI is also highly variable from one night to another. Thus, AHI is limited in describing the short- and long-term consequences of ongoing respiratory events overnight.
The team then assessed the relationship between the degree of upper-airway obstruction and ventilatory burden, and the relationship between ventilatory burden and mortality risks, including
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