Researchers at the Centre for Genomic Regulation (CRG) have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.
Reviewed by Lily Ramsey, LLMAug 25 2023 The findings are published today in the Journal of Cell Biology.
For the spindle to function properly, cells rely on microtubules to 'treadmill'. This involves one end of the microtubule to lose components while the other adds components. The effect is like that of a treadmill conveyor belt, where the microtubules appear to be moving continuously without changing their overall length.
Despite the central role of treadmilling in cell biology, how the process is regulated has remained a mystery – till now. The authors of the study used various isolated proteins known to play a central role in microtubule biology, putting them together in a test tube and visualizing them using a microscope.
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