RExMap unlocks gut microbiome secrets: Revealing their global influence on health Microbiome Aging Genes Genome Nutrition ShotgunSequencing NAR_Open
By Dr. Priyom Bose, Ph.D.Apr 21 2023Reviewed by Danielle Ellis, B.Sc. Several studies have indicated the importance of gut microbes in maintaining human health. These microbes are also associated with fundamental physiologic processes, such as aging, drug response, nutrition, and pathophysiologic states .
Human microbiomes across diverse populations could be studied using the 16S amplicon sequencing technique. This technique uses PCR to amplify and sequence hypervariable regions of bacterial 16S rRNA genes. Amplicon sequencing data are processed through common pipelines, such as Mothur, QIIME2, and DADA2, coupled with computational reconstruction. A taxonomic assignment is carried out by constructing a phylogenic tree using databases such as Greengenes, RDP, and SILVA.
A New Study A recent Nucleic Acids Research study developed a Reference-based Exact Mapping database of 16S hypervariable region variants and their copy numbers. This database was derived from more than 170,000 genomes of microbial isolate strains obtained from the NCBI Genome database. This study used the RExMap database to map microbes at the species level.
Related StoriesThe current study used RExMap to re-analyze the existing human gut microbiome 16S data from 29,349 individuals obtained from ten studies conducted in sixteen different regions of the world.
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