SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19 medrxivpreprint UCT_news LSHTM WitsUniversity lung COVID19 coronavirus covid SARSCoV2 symptom symptoms
By Tarun Sai LomteMar 13 2023Reviewed by Benedette Cuffari, M.Sc. *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Postmortem studies have reported persistent virus in tissues by immunohistochemistry or polymerase chain reaction assay. SARS-CoV-2 detected in these analyses may not be replication-competent, which can only be determined by viral culture. Study findings Culturable virus was detected in 38% of patients for up to four weeks after symptom onset. Contrastingly, in a control cohort of ambulatory subjects, culturable virus was detected in one nasopharyngeal swab sample at day 12 post-onset but not in samples collected on day 19. Notably, multiple organs were positive for SARS-CoV-2 by PCR in Delta cohort decedents who were positive for the culturable virus.
Similarly, an attenuated CD4+ and CD8+ T helper type 1 cell response was observed in cells from the deconstructed lung tissues of decedents from the Delta cohort.
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