SARS-CoV-2 seroprevalence in domestic cats has increased over time biorxivpreprint UofGlasgow SARSCoV2 COVID19 DomesticCats Seroprevalence
By Pooja Toshniwal PahariaNov 22 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers evaluated severe acute respiratory syndrome coronavirus 2 transmission among domestic cats in the United Kingdom .
Residual serum samples were obtained from Glasgow University’s Veterinary diagnostic services laboratory and tested for antibodies against the SARS-CoV-2 spike protein receptor-binding domain by enzyme-linked immunosorbent assays . In addition, pseudotype-based viral neutralization assays were performed to assess SARS-CoV-2 neutralizing antibodies.
The seropositive animals were categorized based on the SARS-CoV-2 pseudotype variant against which the highest neutralizing titers were obtained. In the case of multiple samples from the same animal, the earliest sample was used to estimate seroprevalence. More pedigree cats compared to non-pedigree ones showed SARS-CoV-2 seropositivity, with the highest SARS-CoV-2 seroprevalence among Siamese, British blue/shorthair and Bengal breeds. However, the seroprevalence inter-breed differences were non-significant.
More pedigree cats than non-pedigree ones showed Delta VOC dominance; however, the finding was statistically non-significant. SARS-CoV-2 VOCs were more evenly distributed among non-pedigree cat animals, whereas comparatively fewer pedigree cat animals were B.1-infected. B.1 strain-dominant cats showed marginally lower anti-Alpha titers than anti-B.1 titer, but the anti-Delta and anti-Omicron titers were significantly lower.
Belgique Dernières Nouvelles, Belgique Actualités
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