Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity Organoids SalivaryGland SARSCoV2 Coronavirus Disease COVID StemCell NatureCellBio ColumbiaMed nichidai KobeU_Global
Study: Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication. Image Credit: NIAID
Due to SARS-CoV-2’s ability to infect multiple types of organoids, an organoid culture model could prove apt to demonstrate the infection by SARS-CoV-2 in salivary glands . However, due to a lack of appropriate in vitro models, studies have not been able to elucidate mechanisms underlying SARS-CoV-2 infection and replication in salivary glands and subsequent secretion into saliva.
SRY-box transcription factor 9 gene regulates the development of both mouse and human salivary glands. In its absence, the salivary glands cannot undergo branching morphogenesis. Therefore, the researchers suppressed SOX9 during hiSG induction to elucidate whether hiSGs recapitulated the SOX9-mediated developmental process.
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