Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children RockefellerUniv COVID19 SARSCoV2 MISC
By Bhavana KunkalikarDec 23 2022Reviewed by Aimee Molineux In a recent study published in Science, researchers assessed the inborn abnormalities of 2′-5′-oligoadenylate synthetase -ribonuclease L noted in coronavirus disease 2019 -associated multisystem inflammatory syndrome in children .
The team conducted whole-genome or whole-exome sequencing on 558 MIS-C patients from the COVID Human Genetic Effort international cohort. Homozygous or hemizygous variants predicted to be loss-of-function in human genes and had a gene damage index of less than 13.83 were detected. Consequently, the search was expanded to include all homozygous or probable compound heterozygous nonsynonymous or important splicing site variants having a minor allele frequency of less than 0.
Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Even though RNase L, OAS1, OAS2, and OAS3 are expressed in various mouse and human cell types, their levels are notably high among myeloid cells such as macrophages and monocytes.
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