A team led by scientists from the Trinity Biomedical Sciences Institute (TBSI) has unearthed the possible target for treating the debilitating skin disease hidradenitis suppurativa (HS), which is a painful, chronic, inflammatory skin condition that can last decades.
Despite affecting up to 1% of the population it is often under-recognized and under-diagnosed. Given its high morbidity, reduced quality of life and poorly understood disease trajectory, there is an unmet need for effective therapeutic options, with new treatments badly needed., led by Dr.
Barry Moran and Conor Smith from Trinity's School of Biochemistry and Immunology and Prof. Jean Fletcher from the School of Medicine, the scientists identified significantly increased numbers of proinflammatory immuneAmong other immune populations usually infrequent in healthy skin, these included Th17 cells, B cells,
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