Scientists use enhanced environmental surveillance for poliovirus type 2 detection in London sewage samples ElsevierConnect NIBSC_MHRA Poliovirus Polio Detection Sewage
By Pooja Toshniwal PahariaOct 17 2022Reviewed by Aimee Molineux In a recent study published in The Lancet, researchers investigated molecular properties of type 2 poliovirus isolates obtained from sewage samples to detect PV transmission in communities.
The authors had previously identified two, two, and eight vaccine-like PV isolates of type 1, 2, and 3, respectively, from 2017 to 2021, none of which were genetically related, and all comprised mutations, with no related viruses detected in subsequent WW samples, indicative of no local PV transmission.
In addition, a new nanopore sequencing protocol was used for direct PV detection in stool samples and rapid generation of whole genome PV sequences to improve understanding of their geographical transmission and history. In the modified protocol, type 2 PV isolate-targeted primers were used to improve viral detection sensitivity by decreasing the VP1 sequence background from the co-circulating C enteroviruses species obtained using the original detection protocol.
In total, 118 genetically-associated PV isolates genetically linked to the Sabin 2 vaccine strain were identified in 21 sequential SS obtained in London between 8 February and 4 July 2022. The isolates acquired 11 more mutations between 8 February and 12 April 2022, at differing nt positions, increasing PV genetic diversity.
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