Scientists use single-cell multi-omics data to map disease regulatory circuits Cell Genomics multiomics medrxivpreprint FlatironInst Princeton IcahnMountSinai YaleMed WeillCornell
By Suchandrima BhowmikDec 12 2022Reviewed by Benedette Cuffari, M.Sc. A new study posted to the medRxiv* preprint server applies MAGICAL for identifying modulated host response regulatory circuits in response to Staphylococcus aureus. S. aureus is a bacteria that is mainly resistant to traditional antibiotics; therefore, infection with this pathogen is often severe and associated with high mortality rates.
The impact of disease on regulatory circuits can be determined by mapping regulatory domains with chromatin accessibility changes to altered gene expression concerning cell-type resolution and genomic looping. About the study The current study included 21 patients with culture-confirmed S. aureus bloodstream infection, of which 11 were MSSAs and 10 were MRSA. Twenty-three healthy controls of the same age group as the patients were also included.
Validation of chromatin sites associated with mild COVID-19 was based on PBMC scATAC-seq data from a separate COVID-19 cohort study. In addition, information on Promoter-capture HiC interactions detected in B-cells, CD8 T-cells, CD4 T-cells, and CD14 monocytes, as well as HiCHIP interactions, was obtained.
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