Search for a majordepression trigger reveals a familiar face: Discovery opens new possibilities for treatments sciencemagazine
, and then change the cells' activity? Therein lay the key to understanding vision, pain, memory, behavior and possibly much more, Martemyanov suspected.goes. Fifteen years ago we discovered a binding partner for proteins we were interested in, which led us to this new receptor," Martemyanov said."We've been unspooling this for all this time."
"We were barking up the completely wrong tree before we saw the structure," Martemyanov said."We said, 'Wow, that's an amino acid receptor. There are only 20, so we screened them right away and only one fit perfectly. That was it. It was glycine." Scientists have been cataloging the role of cell receptors and their signaling partners for decades. Those that still don't have known signalers, such as GPR158, have been dubbed"orphan receptors."
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