Macrophages are a type of white blood cell that are among the body's first line of defense against infection. In addition to killing harmful microorganisms, macrophages typically can initiate a response against tumors.
Reviewed by Lily Ramsey, LLMSep 25 2023 However, macrophages, like other cells, can enter a state called senescence, which is linked to aging, disease and multiple physiological problems.
"Conceptually, the idea that a macrophage can become senescent and be tumor-promoting is unexpected," says Darren Baker, Ph.D., a Mayo Clinic senescent cell biologist and senior author of the study. "This finding brings us one step closer to better understanding how tumors and cancer form at the cellular level."
The researchers reasoned that precancerous cells communicated with the surrounding cells, including macrophages, and triggered the macrophages to become senescent. In turn, the senescent cells then appeared to alter the surrounding area in a way that promoted tumor growth. The researchers worked with study co-author Hu Li, Ph.D., an individualized medicine researcher at Mayo Clinic, and conducted single-cell RNA sequencing in his lab. This work helped them identify lung macrophages as a key cell type driving tumor growth. Now, they believe the macrophages are responding to the precancerous cells as they begin to cause tumors.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Researchers develop AI model to improve tumor removal accuracy during breast cancer surgeryArtificial intelligence (AI) and machine learning tools have received a lot of attention recently, with the majority of discussions focusing on proper use. However, this technology has a wide range of practical applications, from predicting natural disasters to addressing racial inequalities and now, assisting in cancer surgery.
Lire la suite »
New AI model improves accuracy of tumor removal in breast cancer surgeryArtificial intelligence (AI) and machine learning tools have received a lot of attention recently, with the majority of discussions focusing on proper use.
Lire la suite »
Bagnaia questioned over Martin fears as his championship lead is cut againFrancesco Bagnaia was asked if the imperious form of title rival Jorge Martin was worrying him.
Lire la suite »
Pickering’s Farm 1,100 homes decision in Penwortham delayed againThe Lanes designs A decision over whether 1,100 homes can be built in a rural part of Penwortham has been delayed – for a third time. The government ha
Lire la suite »