Significant association found between the rs1205 T-Dom genotype and risk of COVID-19 death or hospitalization among American Indians medrxivpreprint UofNorthDakota UNM Columbia COVID19 coronavirus covid
By Dr. Sanchari Sinha Dutta, Ph.D.Aug 14 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study posted to the medRxiv preprint server, researchers identify an association between the C-reactive protein gene variant rs1205 and coronavirus disease 2019 severity.
Background The COVID-19 pandemic, which was caused by the emergence of the severe acute respiratory syndrome coronavirus 2 , has caused severe damage to both economic and healthcare sectors. To date, the World Health Organization reports that COVID-19 has been responsible for over 768 million infections and 6.9 million deaths.
In the current study, scientists investigate possible associations between CRP gene variants and COVID-19 severity among American Indian Tribal communities. Previously reported candidate variants associated with COVID-19 pathogenesis and clinical outcomes were selected. A total of 21 candidate variants including genes in the interferon response pathway, apolipoprotein E , transmembrane protease, serine 2 , toll-like receptor 3 , human leukocyte antigen complex, and the ABO blood group were selected for the final analysis.
The rs1205 variant is a C/T single nucleotide polymorphism in the 3' untranslated region of the CRP gene. Pre-existing evidence on rs1205 variant has highlighted its ability to alter serum levels of CRP, which is an important component of the innate immune system.
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