New targets for CAR-Tcelltherapy against acutemyeloidleukemia through AI-assisted analysis NatureBiotech
Parts of this work have been performed for the doctoral thesis of M.T., R.G., D.D. and S.D. at Technische Universität München and LMU München. A.G., M.T., R.G., S.L., S.E., C.M. and S.K. submitted patent applications related to this work filed by the LMU München, the University Hospital of the LMU Munich or the Helmholtz Centre Munich. S.K. has received honoraria from TCR2, Inc., Novartis, BMS and GSK. S.K. and S.E.
Overview of 11 scRNA-seq datasets of various healthy tissues used to quantify off-target antigen expression. UMAP plots of 11 scRNA-seq datasets with colors highlighting clustering into respective cell types. Cell annotations were provided by the authors of the respective studies. Current CAR targets in AML were cross-referenced to filters used for the single cell-based target screening approach. OE HSC-/Prog-like: overexpressed on HSC-/Prog-like cells with log fold change > 2 and FDR-adjusted p ≤ 0.01, using a-test with overestimated variance. Red cross: Antigen did not fulfill the respective threshold or criteria. Green check: Thresholds or criteria were passed.
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