Smoking alters lung microbiome, leading to loss of diversity and community structure lung microbiome smokingimpact respiratoryhealth microbialdiversity microbialcommunity microbialcooccurrence microbialrivalry smoking MicrobioSoc
By Bhavana KunkalikarApr 26 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Access Microbiology, researchers explore the composition of the microbiome and interactions in the lower respiratory tract in smokers.
The upper airways and oral cavities may also directly interact with smoking chemicals, microbes, and heat from cigarettes, which can alter microbiome content. Recent studies have hypothesized that dysbiosis noted in the oral microbiome related to smoking may lead to a greater likelihood of experiencing complications in the respiratory tract among smokers.
All study participants were required to complete a pulmonary function examination and thorough demographic and clinical questionnaire. The sampling process was standardized for all participants. The team extracted total deoxyribonucleic acid from the bronchoalveolar lavages specimens. Related StoriesOver 3,600 reads with an average length of about 479 nucleotides were documented in each participant's BAL, which facilitated the description of almost 400 operational taxonomic units per participant. The NS profile was sufficiently balanced between the prevalent phyla Bacteroides, Firmicutes, Proteobacteria, and Actinobacteria with comparatively slightly higher proportions.
With respect to the NS profile, a greater number of upper-quartile taxa were distinguished from AS, whereas lower-quartile taxa were distinguished from FS.
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