Twenty years ago, when researchers from the Human Genome Project announced that they had completed the first-ever sequence of an entire set of human DNA, the discovery was heralded as comparable to 'splitting the atom or going to the moon.' The announcement forever transformed the fields of genomics, biology, and medicine, allowing researchers to investigate more complex questions and seek more complicated answers related to the human body and how to treat disease.
Researchers have filled in the final pieces of the puzzle for mapping a complete Y chromosome in humans. Credit: N. Hanacek/NISTthat they had completed the first-ever sequence of an entire set of human DNA, the discovery was heralded as comparable to"splitting the atom or going to the moon.
The Y chromosome is the last of the 24 human chromosomes to be completely sequenced. Credit: Darryl Leja, National Human Genome Research Institute The work benefited from the advancement of sequencing technology, which has come a long way since the Human Genome Project's first sequencing attempt completed in 2003. Long-read sequencing technology, O'Neill explains, is key for successfully interpreting sections of DNA that are highly repetitive.
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