ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors - Nature Immunology

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ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors - Nature Immunology
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Researchers discover how to steer army of immune cells toward cancer natimmunol

We thank the High Content Image Core for help with fluorescence imaging and use of the Dragonfly spinning-disc confocal. We thank Y. Gao and P. Rock for their technical assistance on the manuscript. We especially thank M. Jin for the anti-HER2 CAR DNA construct and for his help with micro-PET/CT imaging, L. Gan for help with βII-spectrin transgenic mouse generation, R. Burack and J. Moore for human sample collections and data review, J. Ashton, D. Ghoneim and J.

Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA Yeonsun Hong, Brandon L. Walling, Hye-Ran Kim, William S. Serratelli, John R. Lozada, Cooper J. Sailer, Andrea M. Amitrano, Kihong Lim, Raj Kumar Mongre, Tara Capece, Kevin Vo & Minsoo KimCooper J. Sailer & Andrea M. Amitrano

Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, KoreaDepartment of Biomedical Engineering, University of Rochester Medical Center, Rochester, NY, USADepartment of Physics and Astronomy, University of Rochester, Rochester, NY, USADepartment of Surgery, University of Rochester, Rochester, NY, USAInstitute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University,...

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