Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment.
Emerging evidence indicates that it is suitable for treating relapsing-remitting MS-; characterized by distinct inflammatory episodes that cause varying degrees of residual disability. But aHSCT has yet to be included in most national clinical guidelines.
How well aHSCT worked was evaluated by analyzing data collected from the Swedish MS registry. And its safety was assessed by scrutinizing the patients' electronic medical records for the 100 days following the procedure. This study showed no evidence of disease activity in nearly 3 out of 4 of those treated after 5 years and in almost two-thirds after 10 years.
Five patients were required intensive care, and 61 developed a bacterial infection within 100 days of treatment. Febrile neutropenia was the most common side effect, affecting 68% of patients.
Belgique Dernières Nouvelles, Belgique Actualités
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