Stinging nettle extract inhibits SARS-CoV-2 cell fusion Cell SARSCoV2 Coronavirus Disease COVID CellFusion biorxivpreprint KU_Leuven UGent
Study: Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern. Image Credit: Craig Walton / Shutterstock
UDA selectively hinders the replication of numerous viruses, including coronaviruses, in different cell kinds. Prior studies with respiratory syncytial virus , human immunodeficiency virus , and influenza virus demonstrated that UDA impedes viral entry, possibly by blocking virus fusion. Initially, the plant lectin UDA was assessed against pseudotyped SARS-CoV-2. Subsequently, the antiviral effectiveness of UDA was examined against the wild-type virus. The team also evaluated UDA against the SARS-CoV-2 Omicron and Delta VOCs.
Results and conclusions The study results indicated that in A549 angiotensin-converting enzyme 2 transmembrane protease serine 2 cells, UDA effectively prevents entry of pseudotyped SARS-CoV-2 with half-maximal inhibitory concentration values varying from 0.32 to 1.22 microM.
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