A new Northwestern Medicine study has discovered a novel therapeutic target and therapeutic agents for older patients with acute respiratory distress syndrome (ARDS), according to recent findings published Aug. 16 in Science Translational Medicine.
Science Translational MedicineA new Northwestern Medicine study has discovered a novel therapeutic target and therapeutic agents for older patients with acute respiratory distress syndrome , according to recent findings published Aug. 16 inApproximately 190,000 Americans are diagnosed with ARDS every year, according to the American Lung Association. The disease occurs when fluid leaks into the lungs, depriving the lungs of oxygen entering the bloodstream.
Using genetic lineage tracing in both aged and young mouse models of ARDS, Zhao's team found that persistent lung injury and high mortality after sepsis due to ARDS were caused by impaired regeneration of endothelial cells in the lungs—cells that linein the lungs to regulate the exchange of oxygen between the bloodstream and surrounding tissue—and lung repair.
"Employing an endothelium-targeted nanoparticle to deliver FOXM1 to the vascular endothelial cells in aged mice could reactivate the regenerative and reparative program and promote survival after sepsis," said Zhao, who also is a professor of pulmonary and critical care medicine and of pharmacology at Feinberg.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment | Journal of Experimental MedicineOncolytic viruses induce tumor lysis and inflame the tumor microenvironment but do not relieve immunosuppressive signals. Engineering oncolytic vaccinia virus t
Lire la suite »
I want to leave medicine but still use my knowledge — where do I start?\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
Lire la suite »
Culinary medicine: Dietary approaches to chronic diseaseA new article in the Journal of Healthcare Leadership advocates for the integration of culinary medicine programs into health care and medical education.
Lire la suite »
Bank of England must reverse interest rate risesWe are treating the disease with the wrong medicine
Lire la suite »
Study shows arterial stiffness as a novel cause of premature heart damage among adolescentsArterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up study.
Lire la suite »
Arterial stiffness may cause and worsen heart damage among adolescentsArterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up study. The study was conducted in collaboration between Texas Children's Hospital and Baylor College of Medicine in the U.S., the University of Bristol in the U.K., the University of Exeter in the U.K., and the University of Eastern Finland. The results were published in Atherosclerosis.
Lire la suite »