Researchers investigated the differential impact of HIV/tuberculosis co-infection on lipid and metabolic profiles.
By Vijay Kumar MalesuAug 23 2023Reviewed by Sophia Coveney In a recent study published in the BMC Infectious Diseases, a group of researchers investigated the differential impact of human immunodeficiency viruses / tuberculosis co-infection on lipid and metabolic profiles.
Participants were South African adults from specific regions in Cape Town, aged between 18 and 69 years. Samples were categorized based on HIV and TB status and treatment. Study results The study revealed that after examining various compounds, 529 were initially detected. However, post-data cleaning, many significant metabolites could not be annotated due to issues like low signal-to-noise ratios, unsuccessful deconvolution, or library absence.
These metabolites seem to correlate with CD4 T-cell counts, as they were diminished in the group, showing a severe disease state based on these counts. The results point to significant metabolic changes in those with the co-infection. Further, it was found that certain metabolites related to lipid and protein metabolism were observed to decrease, suggesting an advanced stage of disease in those with a lower CD4 T-cell count.
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