Researchers investigated the relationship between diet and the proteome.
By Neha MathurAug 22 2023Reviewed by Sophia Coveney In a recent article posted to the medRxiv* server, researchers investigated the relationship between diet and the proteome, defined as the set of circulating proteins at a given time in a type of cell, tissue, or the whole organism.
Previous studies have examined the effects of dietary habits on circulating levels of amino acids. However, there is a lack of data on how plant-based diets affect the proteome. Based on this information, the team included White and British Indian people in this study. The British Indian population had 25% vegetarians compared to <2% in the general population; thus, their inclusion allowed valid comparisons by diet groups.
Furthermore, the team conducted a principal component analysis to account for high correlations between the circulating proteins and multiple testing in the complete proteins dataset. They also assessed overall heterogeneity between diet groups in each ethnicity and pairwise comparisons of all diet groups and the reference groups using Wald tests.
These findings suggested that the impact of the dietary habits of white British participants was more significant on the plasma proteome than on British Indians. However, since this study covered a small sample of British Indians, further research with a larger sample size is needed to confirm these findings.
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