Study explores the potential use of anti-thymic stromal lymphopoietin monoclonal antibody as an adjuvant in allergic immunotherapy UofCalifornia AllergicImmunotherapy Rhinitis Treatment
By Dr. Chinta SidharthanNov 3 2022Reviewed by Aimee Molineux In a recent study published in the Journal of Allergy and Clinical Immunology, a team of researchers from the United States investigated the impact of a monoclonal anti-thymic stromal lymphopoietin antibody on subcutaneous allergen immunotherapy efficacy among patients with allergic rhinitis.
The epithelial-derived cytokine TSLP is known to stimulate the production of T helper type 2 cells and activate eosinophils, mast cells, and type 2 innate lymphoid cells, increasing sensitivity and inflammation during allergies. Patients with severe asthma have been administered tezepelumab, an anti-TSLP monoclonal antibody, and have reported improved lung function and overall outcomes.
The randomized groups received one of four therapeutic regimens comprising cat allergen SCIT and tezepelumab, only cat allergen SCIT, tezepelumab, or a placebo for a 52-week duration, which was followed by a 52-week observation period. Additionally, ribonucleic acid was extracted from cells procured by nasal brushing and used for whole genome transcriptional profiling.
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