Study finds α5 integrin as a potential therapeutic target in amyotrophic lateral sclerosis PNASNews integrin therapeutic target ALS
By Susha Cheriyedath, M.Sc.Aug 3 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Proceedings of the National Academy of Sciences Journal, researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral sclerosis disease.
There has been discussion about whether inflammation is a cause or result of ALS. A systems immunology analysis using mass cytometry predicted the proinflammation role of α-integrins in late-stage of superoxide dismutase-1 G93A mice microglia and peripheral nerve macrophages. Twenty female SOD1G93A mice were randomly divided into two groups of 10 mice, each receiving biweekly intraperitoneal injections of anti-α5 integrin antibody or isotype control starting at eight weeks old.
Anti-α5 integrin antibody-treated SOD1G93A and isotype control mice underwent spinal cord histopathology tests. The Zeiss Apotome.2 on an Axio Imager with Zen v3.5 software was used to analyze both mice groups' spinal cords and sciatic nerves. The presence of positive myeloid cells for α5 integrin promotes inflammation and axonal degeneration because these cells attract more macrophages.
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