Study finds highly specific polygenic signatures across multidimensional symptoms of bipolar disorder TheLancetPsych research polygenic bipolar disorder symptoms
By Neha MathurJul 13 2023Reviewed by Lily Ramsey, LLM In a recent article published in The Lancet Psychiatry, researchers analyzed the relationships between polygenic liability for bipolar disorder, schizophrenia, and major depressive disorder to stratify heterogeneous, multidimensional symptoms of bipolar disorder.
Another intriguing observation comes from family studies suggesting that there is independent transmission of the core symptom dimensions of bipolar disorder, MDD, and psychosis. Thus, despite their clinical concordance, they seem to be etiologically distinct. About the study In the present study, researchers extensively searched multiple databases, viz., MEDLINE, and PsychINFO, to name a few, and systematically identified all relevant literature published in English between January 1, 2006, and September 15, 2022, that used contemporary approaches for genomic stratification of mood disorders.
Related StoriesInclusion criteria for enrolment into this study were that individuals were 18 years or older at the time of the interview, were of European ancestry , lived in the United Kingdom , and registered with the BDRN. The multiple indicator multiple causes model allowed researchers to explore the patterns of complex associations between polygenic liability indexed by disease symptoms, their dimensionality, and polygenic risk scores .
Results In total, 4,198 individuals were eligible for inclusion in this study; however, only 4,148 individuals of EA living in the UK with a median age of 45 years at the SCAN interviews constituted the analysis sample set, of which 2,804 and 1,344 were female and male, respectively. Conclusions The study results challenged current diagnostic systems and highlighted that dimensional representations of bipolar disorder could accommodate problems related to poorly explained mixed psychiatric states with the same symptom presentation.
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