Study finds impaired beta cell function associated with severe COVID-19-induced hyperglycemia Nature betacell covid COVID19 SARSCoV2 hyperglycemia
By Neha MathurJul 19 2023Reviewed by Sophia Coveney In a recent study published in Nutrition & Diabetes, researchers performed an observational prospective cohort study, COVID-19 metabolic and nutritional consequences , in Prague, Czech Republic, between March and November 2021 among adult short-term survivors of coronavirus disease 2019 .
IR decreases skeletal muscle and liver insulin sensitivity as a stress response because catecholamines and cortisol demand are high during the acute phase of COVID-19. It also increases lipolysis and elevates circulating non-esterified fatty acids . About the study In the present study, researchers screened patients at specialized COVID-19 wards of the University Hospital Královské Vinohrady in Prague during March–April 2021, as soon as oxygen support was removed, i.e., baseline .
Additionally, they performed an oral glucose tolerance test per standard WHO recommendations, where an insulinogenic index indicated insulin secretion levels. Further, they calculated the oral disposition index to determine the beta cell function of all participants. The prevalence of hyperglycemia at baseline was 65% in the study population, and it remained as high as 50% up to T6, of which 10 developed prediabetes, while three needed pharmacological treatment for type 2 diabetes. The researchers noted baseline glycated hemoglobin levels >48 mmol/mol in the hyperglycemic group comprising seven patients.
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