Study shows emerging Omicron sublineages efficiently evade neutralization independent of immunization history TheLancetInfDis DPZ_eu uniGoettingen Omicron COVID19 coronavirus covid immunization
By Neha MathurDec 12 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in The Lancet Infectious Diseases, researchers evaluated the effects of hybrid immunity and booster vaccination on Omicron sublineages.
More recently developed bivalent mRNA vaccines use the S proteins of both - the B.1 lineage and Omicron BA.5 sublineage. They have shown good immunogenicity against Omicron sublineages in mouse models. However, data on their effectiveness in humans is inadequate. The team first tested neutralization sensitivity to antibodies elicited by three doses of a vaccine regimen and subsequent monovalent and bivalent boosting. Next, they tested the effect of vaccination plus breakthrough infection by BA.1/BA.2/BA.5 sublineages.
Breakthrough infections by BA.1/BA.2.BA.5 in triply vaccinated individuals induced 3.7 to 8.5 times higher Omicron sublineage neutralization. However, triple vaccination, BA.2/BA.1 breakthrough infection, and a subsequent bivalent vaccine attained the highest Omicron sublineage neutralization. Together, this combination induced 17.6 times more neutralization than triply vaccinated individuals with no breakthrough infection by BA.1/BA.2.
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