A published study by researchers at the University of Cincinnati Cancer Center and Cincinnati Children's Hospital Medical Center shows that multiple beams and intervals in delivery during FLASH proton therapy treatment reduced skin-saving effects in preclinical models.
program within the Center."However, for treatment of patients, multiple beams are required to diminish the exposure of normal tissue to radiation and to make sure the entire area identified for treatment is targeted. The administration of these beams are separated by minutes to allow patient and equipment repositioning.
"The treatment was delivered as one, two or three equal beams with an interruption of two minutes simulating the clinical experience of patients," explained Sertorio. Sertorio says that the single beam delivery showed a maximum benefit to skin, but when it was interrupted for two minutes and then readministered in the same area, it reduced the FLASH skin-saving effect. After two interruptions, the skin tissue-sparing effect was further eliminated.
"Our results indicate that the FLASH skin-sparing effect in areas of beam overlap were diminished by multiple beams as opposed to single beams," he says."This study suggests the number of beams and the spatial arrangement of those beams are important parameters for FLASH studies. Furthermore, the effect of multibeam delivery is likely different for different organs of interest.
"This study is important because it informs the clinical translation of FLASH radiotherapy, with respect to beam delivery modalities, treatment planning and radiation prescriptions," says co-author Anthony Mascia, Ph.D., of Cincinnati Children's."We need to identify where FLASH works and where FLASH doesn't work to move forward.
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