Study shows the emerging Omicron sublineage BA.2.75 does not show greater immune evasion than BA.5 biorxivpreprint karolinskainst UCT_news ETH Omicron SARSCoV2 COVID19 coronavirus covid
By Tarun Sai LomteJul 27 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers assessed the sensitivity of severe acute respiratory syndrome coronavirus 2 Omicron BA.2.75 variant to neutralizing antibodies .
About the study In the present study, researchers evaluated the sensitivity of the spike protein of SARS-CoV-2 Omicron BA.2.75 to neutralization by serum and clinical and preclinical mAbs. Serum samples were obtained from anonymized donors from week 45 of 2021 and week 15 of 2022, representing pre- and post-Omicron BA.1/2 waves. Twenty samples were randomly selected from each timepoint after screening for detectable neutralizing activity against the B.1 variant.
Findings The authors observed a 13-fold lower neutralization potency for cilgavimab against SARS-CoV-2 BA.2.75 relative to B.1, consistent with its reported activity against BA.5. Although weakly neutralizing against BA.2, tixagevimab restored neutralization against BA.2.75, perhaps, due to the reversion to wild-type residue at spike position 493.
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