Study suggests relationship between maternal COVID vaccination, SARS-CoV-2 placentitis, and stillbirth Coronavirus Disease COVID Pregnancy SARSCoV2 placentitis Stillbirth GWtweets MassGeneralNews ChildrensNatl
By Dr. Priyom Bose, Ph.D.Oct 18 2022Reviewed by Benedette Cuffari, M.Sc. Since the beginning of the coronavirus disease 2019 pandemic, several pregnancy complications and adverse clinical outcomes have been observed in both the mother and fetus following infection with the severe acute respiratory syndrome coronavirus 2 .
Another large-scale cohort study conducted in England reported a high rate of fetal death in those infected with SARS-CoV-2 as compared to uninfected mothers. Based on one population-based study, the U.S. Centers for Disease Control and Prevention confirmed the relationship between SARS-CoV-2 infection and stillbirths.
SARS-CoV-2-infected mothers have been found to be at a high risk of placentitis, which is inflammation in the placenta. Mechanistically, massive perivillous fibrin deposition , trophoblast necrosis, and chronic histiocytic intervillositis contribute to fetal demise. Importantly, both MPFD and CHIV were rarely found in the placenta prior to the COVID-19 pandemic.
Can maternal COVID-19 vaccination prevent stillbirths? In the early phase of the COVID-19 vaccination rollout, pregnant women were under-vaccinated. This was because most of the clinical studies that evaluated the safety and efficacy of newly developed COVID-19 vaccines excluded pregnant women due to the limited safety data on messenger ribonucleic acid vaccines.
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Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study - BMC MedicineBackground Regular vaccination against SARS-CoV-2 may be needed to maintain immunity in ‘at-risk’ populations, which include healthcare workers (HCWs). However, little is known about the proportion of HCWs who might be hesitant about receiving a hypothetical regular SARS-CoV-2 vaccination or the factors associated with this hesitancy. Methods Cross-sectional analysis of questionnaire data collected as part of UK-REACH, a nationwide, longitudinal cohort study of HCWs. The outcome measure was binary, either a participant indicated they would definitely accept regular SARS-CoV-2 vaccination if recommended or they indicated some degree of hesitancy regarding acceptance (probably accept or less likely). We used logistic regression to identify factors associated with hesitancy for receiving regular vaccination. Results A total of 5454 HCWs were included in the analysed cohort, 23.5% of whom were hesitant about regular SARS-CoV-2 vaccination. Black HCWs were more likely to be hesitant than White HCWs (aOR 2.60, 95%CI 1.80–3.72) as were those who reported a previous episode of COVID-19 (1.33, 1.13–1.57 [vs those who tested negative]). Those who received influenza vaccination in the previous two seasons were over five times less likely to report hesitancy for regular SARS-CoV-2 vaccination than those not vaccinated against influenza in either season (0.18, 0.14–0.21). HCWs who trusted official sources of vaccine information (such as NHS or government adverts or websites) were less likely to report hesitancy for a regular vaccination programme. Those who had been exposed to information advocating against vaccination from friends and family were more likely to be hesitant. Conclusions In this study, nearly a quarter of UK HCWs were hesitant about receiving a regular SARS-CoV-2 vaccination. We have identified key factors associated with hesitancy for regular SARS-CoV-2 vaccination, which can be used to identify groups of HCWs at the highest risk of vaccine hesitancy and tailor
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Using traveler arrival COVID-19 screening data for real-time SARS-CoV-2 surveillanceIn a new study, researchers developed a model to reconstruct the estimates of how many travelers would have tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive at the country of departure.
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Researchers assess wastewater sampling for SARS-CoV-2 surveillanceResearchers assessed the feasibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surveillance using wastewater sampling.
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Antimicrobial coating reduces spread of SARS-CoV-2 on public transportAntimicrobial coating reduces spread of SARS-CoV-2 on public transport Coronavirus Disease COVID SARSCoV2 Coating Antimicrobial PublicTransport biorxivpreprint UKHSA
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Reduced initiation and duration of breastfeeding in SARS-CoV-2-positive mothersA recent study published in the journal Academic Pediatrics evaluated the associations between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and early breastfeeding.
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Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2In a new study, researchers outlined the synthesis and the possible mechanism of action (MOA) of two potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) repurposing drug candidates.
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