Synergistic winter flounder antimicrobial peptides unveil new path to enhanced bactericidal therapy Nature_NPJ winterflounder antimicrobialpeptides bactericidal therapy
By Vijay Kumar MalesuAug 14 2023Reviewed by Lily Ramsey, LLM In a recent study published in NPJ Antimicrobials and Resistance, a group of researchers investigated the synergistic action of six winter flounder antimicrobial peptides against bacterial pathogens, uncovering the therapeutic potential of combining potent and weakly active peptides.
About the study In the present study, peptides were sourced from Cambridge Research Biochemicals, and further refined with water/acetonitrile gradients. Lipids came from Avanti Polar Lipids, Inc. and were used unpurified. Using multiple antibiotic and bacterial strains, the in vitro pharmacodynamic assays observed bacterial behavior under varying antimicrobial exposure. The bacterial growth rate under the antimicrobial influence was plotted and analyzed. Galleria mellonella larvae tested the antimicrobial efficiency of various treatments on a burn wound infection model.
Study results In the present study, the researchers examined the antimicrobial activity of six WF AMPs on bacterial isolates. Two representative Vibrio isolates were included due to the marine origin of WF peptides. It was observed that WF2 and WF1a-1 showed high antimicrobial potency. Notably, each WF AMP participated in at least one synergistic combination. Lastly, researchers explored whether D-WF1a synergizes with D-pleurocidin or its analog, D-pleurocidin-KR.
The combination of WF AMPs showed a significant enhancement in their therapeutic efficacy, according to research conducted on an invertebrate burn wound infection model using Galleria mellonella larvae. The research further delved into the molecular intricacies behind the synergistic effect of these WF AMPs. It was observed that although certain peptides shared sequence similarities, their antibacterial properties and synergistic potential differed markedly.
Belgique Dernières Nouvelles, Belgique Actualités
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