Good news for patients with acquired or congenital immunodeficiency: The results of a clinical phase II study at the University Hospital Tübingen led by Prof. Dr. Juliane Walz and Prof. Dr. Helmut Salih show an effective activation of T cells against the coronavirus. After showing positive results in healthy volunteers in the previous phase I, the T-cell activator CoVac-1 reproduced these effects in cancer patients for the first time. The results have been published in the journal Nature Communications.
such as SARS-CoV-2 pose a serious threat to patients with weakened immune systems. This group includes, in particular, cancer patients who, due to their disease itself or due to tumor therapy, are unable to mount an adequate immune response following natural infection or with conventional vaccines. These patients often do not develop antibodies against the viral disease.with the aim of better protecting immunocompromised patients against infectious diseases.
and showed good tolerability with very good immune stimulation, i.e., very strong activation of T cells.A total of 54 patients were vaccinated once as part of the study. Most of the study participants suffered from blood cancers and showed a significantly weakened immune system due to the disease itself or the tumor therapy. There were little to no side effects. Only a few mild complaints such as headaches and fatigue were reported.
The long-lasting effect is particularly noteworthy. Thus, even four weeks after vaccination, the broad and strong T-cellwas detected. In initial follow-up studies, these immune responses remained unchanged in strength. Even in severely immunocompromised patients, the T-cell responses activated by CoVac-1 are significantly more pronounced than in recovered individuals after natural infection and also more potent than the T-cell immunity generated by licensed mRNA or vector vaccines.
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