Targeting tau, the other protein behind Alzheimer's disease uwmedicine PNASNews
Tau, which rhymes with"wow," stabilizes crucial structures within cells, called microtubules. These structures serve as a cell's internal skeleton and act as conduits through which the cell shuttles material from place to place.
"If we were to target any one thing in Alzheimer's disease, we probably should be targeting tau," Kraemer said."It's the most closely tied to the decline in cognitive dysfunction. You want to get rid of amyloid but what you really want is preservation of cognition. That requires targeting tau."on Dec.
The exact role the protein plays in diseases involving tau is not clear. But it appears to be involved in an essential process by which cells handle and eliminate defective proteins. The findings suggest that if drugs could be developed that inhibit the effect of this protein it might be possible to treat Alzheimer's disease and other tauopathies.his lab created two decades ago.
The researchers then conducted a screen of all the genes in the worm to see if randomly knocking out any of them could prevent these changes. This approach led them to first identify the gene for SUT-2 and more recently SPOP.
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