Interfering with antiviral pathway may deter Alzheimer'sdisease and frontotemporaldementia WeillCornell NatureNeuro
7.4). Slices were then kept at room temperature in oxygenated ACSF until recordings were performed. Field recordings were performed in the dentate gyrus molecular layer of the acute horizontal brain slices placed in a recording chamber. Slices were submerged in oxygenated ACSF that was continuously perfused at 30 °C. The glass recording electrode was filled with ACSF and lowered ~50 µm into the molecular layer of the dorsal blade of the dentate gyrus.
. Cells were then further differentiated into microglia-like cells via a 13-d culture with macrophage colony-stimulating factor and interleukin-34 and TMEM119 . iPSC-derived microglia were pretreated with 20 µM TDI-8246, 2 or 5 µM H-151 or 0.2% DMSO control for 6 h, followed by 0N4R tau fibril treatment overnight for 18–20 h.BV2 microglia were transfected with mouse IFNβ reporter plasmid, pNiFty3-I-Lucia , using Lipofectamine 2000 .
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