Critically ill children exposed to hypoglycemia in PICU are at higher risk of impaired executive functions after 4 years, especially in cases of spontaneous/recurrent hypoglycemia, finds a study published in Crit_Care.
First, the association between hypoglycemia in PICU and mortality and long-term neurodevelopmental outcomes was investigated by univariable comparison and by multivariable regression analyses adjusted for baseline risk factors. Baseline risk factors were age, sex, treatment center, randomization to Early-PN or Late-PN, severity of illness upon PICU admission , risk of malnutrition , admission diagnostic category, history of malignancy, diabetes, and a predefined syndrome.
Since our group had previously observed elevated baseline NSE and S100B in patients who subsequently developed hypoglycemia as compared with those who did not, we repeated the multivariable regression analyses described above, in the subset of patients with available blood sample, further adjusting for the upon-admission NSE and S100B concentrations as biomarkers of baseline neuronal and astrocytic damage.
For those outcomes revealing a consistent significant independent association with hypoglycemia, sensitivity analyses were performed to investigate whether an episode of iatrogenic hypoglycemia differentially associates with outcome as compared with spontaneous or recurrent hypoglycemia, first in univariable comparison and thereafter in multivariable regression analysis adjusting for baseline risk factors, mean morning blood glucose, glucose variability, and length of PICU stay.
Data are presented as frequencies and percentages, mean , or median , as appropriate. We performed Chi-square and Fisher’s exact test, Wilcoxon rank-sum or Kruskal–Wallis test to study univariate comparisons, and multivariable logistic and linear regression analyses to study multivariable comparisons, as appropriate. Two-sided-values < 0.05 were considered statistically significant, without correction for multiple comparisons. To study interactions, interaction-values < 0.
. Patients with hypoglycemia were significantly younger , more often treated in Leuven , more frequently randomized to Late-PN and categorized in different diagnostic groups , with a higher baseline illness severity score than patients without hypoglycemia. Mean morning blood glucose was significantly lower, glucose variability was larger, and PICU stay was significantly longer .
Belgique Dernières Nouvelles, Belgique Actualités
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No country can solve critical mineral shortages alone\n\t\t\tExpert insights, analysis and smart data help you cut through the noise to spot trends,\n\t\t\trisks and opportunities.\n\t\t\n\t\tJoin over 300,000 Finance professionals who already subscribe to the FT.
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Ukraine war is at a critical moment - and Zelenskyy needs some good newsSince the start of Ukraine's counteroffensive against Russia, there has been limited good news for Kyiv, Sean Bell writes - but President Volodymyr Zelenskyy will be banking on its success.
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