A Review published in Biology Direct describes the current state of molecular profiling in gastrointestinal cancers and summarizes the preparation for the journey ahead.
]. The clinical role of CTCs is currently limited but is expected to expand on the heels of technology improvements, including CTC-isolation and organoid-development techniques.Tissue molecular profiling provides clinically significant subtyping of all GI cancers. The liquid biopsy promises dynamic tumor characterization through various platforms, and we believe these capabilities will be increasingly incorporated into clinical cancer management.
As liquid biopsy techniques improve, blood-based testing will hopefully better identify MRD and screen early-stage GI tumors with hopes of curing more patients and improving outcomes.Molecular profiling for patients with GI malignancies is clearly making an impact and has become the standard of care in many situations. In fact, in 2021, ASCO chose molecular profiling in GI cancers as its Advance[ment] of the Year [].
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