The effect of vaccination-induced immunity on viral loads of SARS-CoV-2 Omicron variant NatureComms TelAvivUni vaccination vaccine Omicron immunity COVID19 coronavirus covid
By Dr. Chinta SidharthanNov 9 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Nature Communications, researchers analyzed nationwide vaccination data and cycle threshold value data from four laboratories in Israel that conduct severe acute respiratory syndrome coronavirus 2 quantitative reverse transcription polymerase chain reaction tests to determine the effect of vaccination-induced immunity on the viral loads of the SARS-CoV-2 Omicron variant.
About the study In the present study, the researchers conducted a retrospective analysis using vaccination data and records of positive SARS-CoV-2 PCR tests, including the cycle threshold values from four major Israeli Health Maintenance Organization laboratories. Multiple positive tests for the same individual within a span of 90 days were considered a single infection.
A multivariate linear regression analysis was conducted for the cycle threshold values with vaccination status, age, sex, calendar time, and laboratory used as covariates. The analysis was also conducted separately for PCR tests that amplified the SARS-CoV-2 nucleocapsid gene and those that measured the envelope gene.
The cycle threshold values for PCR tests during the Omicron period were seen to increase in response to a recent third vaccine dose but were not significantly different for the unvaccinated, two-dose, and late three-dose group patients. The results indicated that the effect of the vaccination-induced immunity was lower for the Omicron variant than for the Delta variant.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Hybrid immunity from vaccination and Omicron BA.1 or BA.5 breakthrough infections exhibits cross-reactive efficacy against BA.2.75Researchers recently measured the neutralizing antibody titers against the wild-type strain of SARS-CoV-2 and the SARS-CoV-2 Omicron subvariants in healthcare workers fully vaccinated with three doses of the Comirnaty vaccine who experienced breakthrough Omicron infections.
Lire la suite »
Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral responseThis study shows that SARS-CoV-2 infection leads to activation of the Hippo signaling pathway in human COVID-19 lung tissue and cultured cells. The Hippo signaling pathway appears to play an antiviral role, and pharmacological inhibition of the downstream transactivator YAP reduces SARS-CoV-2 replication, with therapeutic implications.
Lire la suite »
Study indicates widespread SARS-CoV-2 exposure in wildlifeIn a recent study posed to the bioRxiv* preprint server, researchers at Virginia Tech University investigated wildlife exposure to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
Lire la suite »
SARS-CoV-2 activates NLRP3 inflammasomeResearchers assessed the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation.
Lire la suite »
Study shows consistent efficacy of Paxlovid regardless of age, number of vaccinations, comorbiditiesIn a recent study posted to the medRxiv* preprint server, researchers in Canada evaluated nirmatrelvir and ritonavir (Paxlovid) effectiveness against severe coronavirus disease 2019 (COVID-19) during the dominance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) and Omicron sub-VOCs in Canada.
Lire la suite »
SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis - Communications BiologySARS-CoV-2 protein expression studies in the Drosophila heart suggest a cause of COVID-19-associated cardiac pathology via interaction of virus Nsp6 with the host MGA/MAX complex disrupting glycolysis and cardiac mitochondrial function.
Lire la suite »