The effectiveness of antimicrobial mouthwashes in reducing viral load in saliva of COVID-19 patients SciReports QMUL ucl mouthwash dental COVID19 coronavirus covid SARSCoV2 virus antimicrobial
By Dr. Priyom Bose, Ph.D.Aug 9 2023Reviewed by Benedette Cuffari, M.Sc. The coronavirus disease 2019 pandemic, which was caused by the rapid transmission of the severe acute respiratory disease coronavirus 2 , has claimed more than 6.9 million lives worldwide. SARS-CoV-2 is easily transmitted to healthy individuals through exposure to infected droplets that are generated by an infected person while talking or coughing.
Background SARS-CoV-2 is an enveloped virus that contains an outer lipid membrane. The SARS-CoV-2 spike protein binds with the angiotensin-converting enzyme II receptor of the host to establish infection. ACE2 is significantly expressed in the oral cavity and oral epithelial cells. Previous studies have reported that certain constituents of mouthwash and toothpaste can disrupt the SARS-CoV-2 envelope protein, which could effectively inactivate SARS-CoV-2 and prevent viral transmission.
To date, there remains a lack of data on how mouthwashes containing CHX, hydrogen peroxide , and CPC affect the viral load of various SARS-CoV-2 strains in saliva. The current study included patients between 18 and 74 years of age who were diagnosed with COVID-19 and hospitalized at the Newham University and Royal London Hospitals between April and October 2021. During this period, the SARS-CoV-2 Delta variant was the dominant circulating strain.
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