The effectiveness of psychological therapies in patients with inflammatory bowel disease TheLancet psychologicaltherapies inflamatoryboweldisease IBD IBS gutbrainaxis
By Dr. Priyom Bose, Ph.D.Aug 8 2023Reviewed by Benedette Cuffari, M.Sc. The influence of the gut-brain axis on inflammatory bowel disease has been highlighted in many studies, which indicate the potential of psychological therapies being effective in treating people with IBD. However, the available data on this effect is conflicting.
Background IBD is a chronic gastrointestinal condition that can be further subdivided into Crohn’s disease and ulcerative colitis. An increased prevalence of IBD has been observed throughout Europe and North America. Some key factors involved in the development of IBD include reduced integrity of the intestinal barrier, microbial dysbiosis, and immunological dysfunction within the gut.
There remains a lack of studies regarding the efficacy of psychological therapies targeted to the gut-brain axis to alleviate IBD symptoms. Further, it remains unclear whether these therapies positively influence disease activity and improve the psychological health of IBD patients. About the study After publication of the aforementioned meta-analysis, numerous RCTs have been conducted on this topic. In this updated review, the authors consider the most recent publications to assess how psychological therapies influence IBD activity, quality of life, and psychological health of patients.
Study findings A total of 469 new studies were identified in the updated literature search, 11 of which met all eligibility criteria. Fourteen additional studies were included from a previous meta-analysis that was published in 2017. Taken together, the current systematic review and meta-analysis considered a total of 25 RCTs, all of which were at a high risk of bias.
The positive effect of psychological therapies, particularly on anxiety and stress scores, persisted until the final follow-up in people with quiescent IBD. However, a similar level of persistent improvement was not observed for depression scores.
Belgique Dernières Nouvelles, Belgique Actualités
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