A Review published in Cancer Cell International discusses the effects of miR-182 dysregulation on the signaling pathways involved in tumorigenesis and finds that miRNA- 182 can be a promising target in the treatment and diagnosis of various malignancies.
]. The improper expression of these enzymes has been confirmed in many cancers, including CRC. The expression level of ST6GALNAC2 as one of the STs is downregulated in CRC tissues and 5-FU-resistant CRC cell lines. Increased ST6GALNAC2 levels are associated with poor survival in CRC.
tumor suppressor. belongs to the Forkhead box O transcription factor family and plays an important role in the cell cycle. Studies indicated that miR-182 is involved in increasing the invasion, migration, and cell proliferation of prostate cancer by targeting and thus suppressing the translation of this mRNA []. Another study reported that three genes, FOXF2, RECK, and MTSS1, which act as tumor suppressors and are involved in inhibiting the development of prostate cancer cells by reducing invasion and migration, were targeted by miR-182-5p. It should be noted that RECK shows its tumor suppressor function by reducing the invasion of prostate cancer by inhibiting MMP-2.
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