The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins PLOSNTDs IUMedSchool Cambridge_Uni WEHI_research antibody antibodies vaccine malaria
By Suchandrima BhowmikNov 28 2022Reviewed by Danielle Ellis, B.Sc. Malaria is a significant public health threat, causing about 241 million cases worldwide in 2020. Although Plasmodium falciparum is reported to be the most common malaria parasite in Africa, P. vivax is the predominant parasite in most countries in America and Asia Pacific. Critical illnesses caused by P.vivax are no more considered rare events.
Lab Diagnostics & Automation eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today Previous studies in Papua New Guinea children identified several antigens as vaccine candidates, such as Duffy binding protein region II , Pv41, Pv12, RBP2b, RBP1a, PVX_081550, and erythrocyte binding protein . Recent research indicated antibodies to PvRBP2b to protect against clinical malaria in Thailand and Brazil.
A new study in PLOS Neglected Tropical Diseases aimed to evaluate the magnitude, longevity, and prevalence of naturally acquired IgG antibody responses against 9 P. vivax vaccine candidate antigens in patients with acute vivax malaria and were followed up for 180 days. Study findings The results indicated that 37 individuals completed the 30-day follow-up, 19 completed the 60-day follow-up, and 8 completed the 180-day follow-up. Strong and positive correlations of IgG reactivity were observed between PVX_081550, PvGAMA, Pv41, and Pv12 at baseline. A strong correlation for IgG reactivity against PVX_081550 and Pv41 was observed across all four-time points.
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