The international spread of drug-resistant Shigella sonnei NatureComms shigella shigellasonnei amr abr antimicrobialresistance pandemic epidemic publichealth sexualhealth
By Neha MathurApr 12 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nature Communications Journal, researchers examined the international dissemination of the outbreak of extensively drug-resistant Shigella sonnei strain transmitted via men who have sex with men in the United Kingdom .
After S. sonnei acquired resistance to ciprofloxacin, the WHO raised the urgency for new antibiotics against this microbe. In addition, they explored the extent of dissemination of representatives of all S. sonnei subclades, including those assigned a single nucleotide polymorphism address by the United Kingdom Health Security Agency , across UK, France, Belgium, Australia, and the United States of America .
Recently, a study showed that this plasmid inhibited the host SOS response to very low inhibitory concentrations of ciprofloxacin. While p893816 was present in most BAPS 5 isolates, its 2018 ancestor carrying a low-fitness cost resistance plasmid was found previously in an S. flexneri 3a isolate from Australia.
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