The kinetics of SARS-CoV-2 nucleocapsid antibodies up to 21 months after infection EIDjournal CDCgov MassGeneralNews harvardmed HHI SARSCoV2 COVID19 coronavirus covid infection antibodies
By Tarun Sai LomteJul 28 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Emerging Infectious Diseases, researchers found significant seroreversion of total anti-nucleocapsid immunoglobulin.
About the study In the current study, researchers quantified antibodies against SARS-CoV-2 nucleocapsid among healthcare workers in the United States . Nucleocapsid antibodies act as markers for prior SARS-CoV-2 infection even in the vaccinated population. Over 2300 Brigham and Women’s Hospital employees were included in a longitudinal cohort study between April 28 and September 30, 2020.
Results Related Stories125 participants were positive for antibodies against SARS-CoV-2 nucleocapsid between April 2020 and January 2021, when the wild-type virus was predominantly circulating. Of these, 110 subjects, who had one or more samples after the first seropositive sample, were included in the study. Most participants were females and White ; the median age was 33, with a median body mass index of 24 kg/mm2.
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