The role of estrogen in osteoarthritis and lower back pain UQ_News QIMRBerghofer osteoarthritis arthritis backpain pain estrogen
By Pooja Toshniwal PahariaAug 10 2023Reviewed by Benedette Cuffari, M.Sc. Osteoarthritis pain is a significant issue among older females, with intervertebral disc degeneration and facet joint OA common causes of this condition. The incidence of OA is two-fold greater among women than men, with menopause amplifying this difference.
Study: Low back pain and osteoarthritis pain: a perspective of estrogen. Image Credit: Sasan Paraksa / Shutterstock.com OA is a degenerative condition that worsens over time and ultimately results in persistent discomfort. OA often affects the body's joints, including the spine, hands, hips, and knees.
Role of estrogen in OA and LBP pain Estrogen, a steroid hormone released from human ovaries, plays a crucial role in the growth, differentiation, and normal functioning of female reproductive organs, bone health, and musculoskeletal metabolism. Estrogen deficiency may facilitate IVDD through changes in cartilage endplate remodeling and vertebral osteoporosis. In addition to IVDD, estrogen deficiency may also promote FJOA, as demonstrated in ovariectomized mice with decreased surface area, thickness, and volume, surface subchondral bone damage, and increased osteoclasts within their subchondral bone.
E2/progesterone therapy can improve condylar cartilaginous and vertebral disc health, reduce joint inflammation, and diminish joint nociception. Clinical studies have indicated that estrogen supplementation can reduce the frequency of joint pain among postmenopausal females. In fact, estrogen and estrogen-related medicinal drugs have been shown to reduce the incidence and prevalence of hand, hip, and knee OA and lower arthroplasty rates.
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