There's now an oral treatment for postpartum depression
of the drug in several hundred people with major depressive disorder showed early and rapid improvement of symptoms, but that change wasn't sustained; by the end of the treatment period, there was little difference from the start of the study in patients' depression symptoms as measured by standard tests.
Some women showed improvements as early as the third day of treatment, and the fast-acting effect of the drug could be a game-changer in the treatment of depression. Currently, many people continue to experience symptoms for months after starting existing antidepressant therapies that rely on the brain chemicals serotonin, noradrenalin, or dopamine. Zuranolone promises to relieve those symptoms within days.
The drug’s quick action may be due to how it works in the brain. Zuranolone targets a receptor called GABA-A, which plays a key role in how the brain calms down nerve activity. In women with postpartum depression, this response isn’t regulated as well as it should be, and the stress responses, including those due to hormonal changes caused by pregnancy, aren’t modulated as well, which can lead to imbalances in brain chemicals that contribute to depression.
One reason doctors need to monitor patients while they are given brexanolone is the risk of losing consciousness or passing out during administration. About 26% of the women taking zuranolone in one of theexperienced drowsiness and 11% became sedated, but Deligiannidis says none lost consciousness. “There’s a striking difference,” she says between the side effects seen with brexanolone and zuranolone.
Belgique Dernières Nouvelles, Belgique Actualités
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