Study validates organoids as tool for studying fetal intestine development
differentiation of pluripotent stem cells into human intestinal organoids has served as a powerful means for creating complex three-dimensional intestinal structures. Due to their diverse cell populations, transplantation into an animal host is supported with this system and allows for the temporal formation of fully laminated structures, including crypt-villus architecture and smooth muscle layers which resemble native human intestine.
While the endpoint of HIO engraftment has been well described, here, we aim to elucidate the developmental stages of HIO engraftment and establish if it parallels fetal human intestinal development. We analyzed a timecourse of transplanted HIOs histologically at two, four, six and eight weeks post-transplantation and demonstrated that HIO maturation closely resembles key stages of fetal human intestinal development.
Belgique Dernières Nouvelles, Belgique Actualités
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