Cardiovascular benefits of lipid-lowering drugs apply across ethnicities and regions, study finds
The efficacy of lipid-lowering therapies among different ethnicities and regions remains unclear. We aimed to assess cardiovascular event reductions associated with LLT according to ethnicity and region in previously published randomized clinical trials .Medline, EMBASE and Cochrane CENTRAL were searched for RCTs of statins, ezetimibe or proprotein convertase subtilisin/kexin type 9 inhibitors comparing intensive versus less intensive low-density lipoprotein cholesterol lowering.
There is under-representation of several minority groups such as those from South Africa, South America and Asia, as well as Black, Latin American and Asian ethnicities. Furthermore, among included populations, the benefits of LLT appear to be consistent across regions and ethnicities. The findings of this study highlight the importance of ensuring at-risk patients have access to LLT regardless of ethnicity or region. Future trials should ensure adequate representation of all patient groups.
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