Using CRISPR to Lift the Lid on Probiotics NCState CRISPR genetics probiotics guthealth science innovation
Interview conducted by Emily Henderson, B.Sc.Jul 26 2022 Thought LeadersEcho PanFunctional Genomics Ph.D. StudentNC State University
Probiotics are usually referred to as the “good bacteria”. You can find them in supplements and fermented foods such as yogurt and cheese. Sometimes doctors will recommend patients take probiotics when they are prescribed antibiotics. The idea is that antibiotics tend to wipe out your native microbiome , and probiotics can help restore the normal microbiome. Probiotics have been associated with a range of health benefits such as digestive health, immune health, infant health, brain health, etc.
In your latest research, you looked into the genetics behind Bifidobacterium. Can you tell us how you conducted your research and the genetic tools used? In this paper, we repurposed the endogenous type I-G CRISPR-Cas system and adopted an exogenous CRISPR base editor for genome engineering in B. animalis subsp. lactis.
For your latest research, you used CRISPR-Cas. With this still being a relatively new gene-editing technology, how has this influenced microbiology research? Are you hopeful that with continued advancements in technology, discoveries within microbiology will continue to emerge? Related StoriesIn nature, CRISPR-Cas systems serve as the adaptive immune systems in bacteria again bacteriophage attacks .
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